radiation damage to detector materials (solid state) Search Results


jsm it100 sem  (JEOL)
97
JEOL jsm it100 sem
Jsm It100 Sem, supplied by JEOL, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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carboxyphenol ba  (Chem Impex International)
95
Chem Impex International carboxyphenol ba
Carboxyphenol Ba, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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light microscope zeiss axio a1  (Carl Zeiss)
90
Carl Zeiss light microscope zeiss axio a1
Light Microscope Zeiss Axio A1, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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light eclipse e200 microscope  (Nikon)
99
Nikon light eclipse e200 microscope
Light Eclipse E200 Microscope, supplied by Nikon, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fuse damage  (Littelfuse Inc)
90
Littelfuse Inc fuse damage
Fuse Damage, supplied by Littelfuse Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dm750 inverted light microscope  (Danaher Inc)
97
Danaher Inc dm750 inverted light microscope
Dm750 Inverted Light Microscope, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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x ray induced dna damage  (Rad Source Technologies)
96
Rad Source Technologies x ray induced dna damage
(A) Twelve cell lines were stained for p53 before or 2 hours after treatment with the <t>DNA</t> damaging agent NCS (100 ng/ml). Scale bar, 50μm. “M” marks the 5 melanoma lines. (B) Histograms of single cell straining intensity of p53 before (blue) or after (red) treatment with NCS. Black lines indicate the medians of the distributions. Cells are ordered by their median p53 abundance after NCS. (C and D) A549 cells were stained for p53 2 (C) or 8 (D) hours after a log2 titrations series of NCS doses. Red lines indicate the median of the distribution. The abundance of p53 did not vary significantly across <t>DNA</t> <t>damage</t> doses at 2hrs (pvalue >0.05), but did after 8hrs (pvalue <0.05, unpaired ttest). (E and F) Each cell line was stained for p53 2 (E) or 8 (F) hours after varying doses of NCS. Heatmaps represent p53 abundance. Each cell line was internally normalized (Norm.) between 0 and 1. Data in (B–F) are from N>500 cells for each cell line, representative of 2 independent experiments. AU, arbitrary units.
X Ray Induced Dna Damage, supplied by Rad Source Technologies, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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light microscope bh-2, tokyo, japan  (Evident Corporation)
90
Evident Corporation light microscope bh-2, tokyo, japan
(A) Twelve cell lines were stained for p53 before or 2 hours after treatment with the <t>DNA</t> damaging agent NCS (100 ng/ml). Scale bar, 50μm. “M” marks the 5 melanoma lines. (B) Histograms of single cell straining intensity of p53 before (blue) or after (red) treatment with NCS. Black lines indicate the medians of the distributions. Cells are ordered by their median p53 abundance after NCS. (C and D) A549 cells were stained for p53 2 (C) or 8 (D) hours after a log2 titrations series of NCS doses. Red lines indicate the median of the distribution. The abundance of p53 did not vary significantly across <t>DNA</t> <t>damage</t> doses at 2hrs (pvalue >0.05), but did after 8hrs (pvalue <0.05, unpaired ttest). (E and F) Each cell line was stained for p53 2 (E) or 8 (F) hours after varying doses of NCS. Heatmaps represent p53 abundance. Each cell line was internally normalized (Norm.) between 0 and 1. Data in (B–F) are from N>500 cells for each cell line, representative of 2 independent experiments. AU, arbitrary units.
Light Microscope Bh 2, Tokyo, Japan, supplied by Evident Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/light microscope bh-2, tokyo, japan/product/Evident Corporation
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stem cells translational medicine  (Alphamed INC)
90
Alphamed INC stem cells translational medicine
(A) Twelve cell lines were stained for p53 before or 2 hours after treatment with the <t>DNA</t> damaging agent NCS (100 ng/ml). Scale bar, 50μm. “M” marks the 5 melanoma lines. (B) Histograms of single cell straining intensity of p53 before (blue) or after (red) treatment with NCS. Black lines indicate the medians of the distributions. Cells are ordered by their median p53 abundance after NCS. (C and D) A549 cells were stained for p53 2 (C) or 8 (D) hours after a log2 titrations series of NCS doses. Red lines indicate the median of the distribution. The abundance of p53 did not vary significantly across <t>DNA</t> <t>damage</t> doses at 2hrs (pvalue >0.05), but did after 8hrs (pvalue <0.05, unpaired ttest). (E and F) Each cell line was stained for p53 2 (E) or 8 (F) hours after varying doses of NCS. Heatmaps represent p53 abundance. Each cell line was internally normalized (Norm.) between 0 and 1. Data in (B–F) are from N>500 cells for each cell line, representative of 2 independent experiments. AU, arbitrary units.
Stem Cells Translational Medicine, supplied by Alphamed INC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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axioplan 2 light microscope  (Carl Zeiss)
90
Carl Zeiss axioplan 2 light microscope
(A) Twelve cell lines were stained for p53 before or 2 hours after treatment with the <t>DNA</t> damaging agent NCS (100 ng/ml). Scale bar, 50μm. “M” marks the 5 melanoma lines. (B) Histograms of single cell straining intensity of p53 before (blue) or after (red) treatment with NCS. Black lines indicate the medians of the distributions. Cells are ordered by their median p53 abundance after NCS. (C and D) A549 cells were stained for p53 2 (C) or 8 (D) hours after a log2 titrations series of NCS doses. Red lines indicate the median of the distribution. The abundance of p53 did not vary significantly across <t>DNA</t> <t>damage</t> doses at 2hrs (pvalue >0.05), but did after 8hrs (pvalue <0.05, unpaired ttest). (E and F) Each cell line was stained for p53 2 (E) or 8 (F) hours after varying doses of NCS. Heatmaps represent p53 abundance. Each cell line was internally normalized (Norm.) between 0 and 1. Data in (B–F) are from N>500 cells for each cell line, representative of 2 independent experiments. AU, arbitrary units.
Axioplan 2 Light Microscope, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dm4000b upright light microscope  (Danaher Inc)
96
Danaher Inc dm4000b upright light microscope
(A) Twelve cell lines were stained for p53 before or 2 hours after treatment with the <t>DNA</t> damaging agent NCS (100 ng/ml). Scale bar, 50μm. “M” marks the 5 melanoma lines. (B) Histograms of single cell straining intensity of p53 before (blue) or after (red) treatment with NCS. Black lines indicate the medians of the distributions. Cells are ordered by their median p53 abundance after NCS. (C and D) A549 cells were stained for p53 2 (C) or 8 (D) hours after a log2 titrations series of NCS doses. Red lines indicate the median of the distribution. The abundance of p53 did not vary significantly across <t>DNA</t> <t>damage</t> doses at 2hrs (pvalue >0.05), but did after 8hrs (pvalue <0.05, unpaired ttest). (E and F) Each cell line was stained for p53 2 (E) or 8 (F) hours after varying doses of NCS. Heatmaps represent p53 abundance. Each cell line was internally normalized (Norm.) between 0 and 1. Data in (B–F) are from N>500 cells for each cell line, representative of 2 independent experiments. AU, arbitrary units.
Dm4000b Upright Light Microscope, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dm4000b upright light microscope - by Bioz Stars, 2026-05
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uv-b lamp spectroline xx15b  (Spectronics corporation)
90
Spectronics corporation uv-b lamp spectroline xx15b
(A) Twelve cell lines were stained for p53 before or 2 hours after treatment with the <t>DNA</t> damaging agent NCS (100 ng/ml). Scale bar, 50μm. “M” marks the 5 melanoma lines. (B) Histograms of single cell straining intensity of p53 before (blue) or after (red) treatment with NCS. Black lines indicate the medians of the distributions. Cells are ordered by their median p53 abundance after NCS. (C and D) A549 cells were stained for p53 2 (C) or 8 (D) hours after a log2 titrations series of NCS doses. Red lines indicate the median of the distribution. The abundance of p53 did not vary significantly across <t>DNA</t> <t>damage</t> doses at 2hrs (pvalue >0.05), but did after 8hrs (pvalue <0.05, unpaired ttest). (E and F) Each cell line was stained for p53 2 (E) or 8 (F) hours after varying doses of NCS. Heatmaps represent p53 abundance. Each cell line was internally normalized (Norm.) between 0 and 1. Data in (B–F) are from N>500 cells for each cell line, representative of 2 independent experiments. AU, arbitrary units.
Uv B Lamp Spectroline Xx15b, supplied by Spectronics corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


(A) Twelve cell lines were stained for p53 before or 2 hours after treatment with the DNA damaging agent NCS (100 ng/ml). Scale bar, 50μm. “M” marks the 5 melanoma lines. (B) Histograms of single cell straining intensity of p53 before (blue) or after (red) treatment with NCS. Black lines indicate the medians of the distributions. Cells are ordered by their median p53 abundance after NCS. (C and D) A549 cells were stained for p53 2 (C) or 8 (D) hours after a log2 titrations series of NCS doses. Red lines indicate the median of the distribution. The abundance of p53 did not vary significantly across DNA damage doses at 2hrs (pvalue >0.05), but did after 8hrs (pvalue <0.05, unpaired ttest). (E and F) Each cell line was stained for p53 2 (E) or 8 (F) hours after varying doses of NCS. Heatmaps represent p53 abundance. Each cell line was internally normalized (Norm.) between 0 and 1. Data in (B–F) are from N>500 cells for each cell line, representative of 2 independent experiments. AU, arbitrary units.

Journal: Science signaling

Article Title: Dynamics of p53 in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM

doi: 10.1126/scisignal.aah6671

Figure Lengend Snippet: (A) Twelve cell lines were stained for p53 before or 2 hours after treatment with the DNA damaging agent NCS (100 ng/ml). Scale bar, 50μm. “M” marks the 5 melanoma lines. (B) Histograms of single cell straining intensity of p53 before (blue) or after (red) treatment with NCS. Black lines indicate the medians of the distributions. Cells are ordered by their median p53 abundance after NCS. (C and D) A549 cells were stained for p53 2 (C) or 8 (D) hours after a log2 titrations series of NCS doses. Red lines indicate the median of the distribution. The abundance of p53 did not vary significantly across DNA damage doses at 2hrs (pvalue >0.05), but did after 8hrs (pvalue <0.05, unpaired ttest). (E and F) Each cell line was stained for p53 2 (E) or 8 (F) hours after varying doses of NCS. Heatmaps represent p53 abundance. Each cell line was internally normalized (Norm.) between 0 and 1. Data in (B–F) are from N>500 cells for each cell line, representative of 2 independent experiments. AU, arbitrary units.

Article Snippet: X-ray induced DNA damage was generated with a RS-2000 source (RadSource).

Techniques: Staining

(A) A549 cells expressing p53-YFP were pre-treated with DMSO (NT) or Olaparib (PARPi; 10uM), NU7026 (DNA-PKi; 10uM), or CH99021 (GSK3βi; 10uM) for 1hr and then treated with NCS (100 ng/ml). Red lines represent the treated condition (thin lines, single cells; thick line, average), and the blue line represents the control (NT) cells (N>40 cells, representative of 2 independent experiments.). (B) Quantification of γH2AX intensity induced by NCS (100ng/ml; DNA damage) was measured in A549 cells after 1hr pretreatment with DMSO (NT) or the indicated inhibitor (10uM) 6 hours after treatment with 10Gy IR. Scale bar, 25μm. Histograms are shown, with a red line indicating the median (N>500 cells, representative 3 independent experiments.). (C) Images of cells from the indicated lines stained for γH2AX before or 0.5 or 24 hours after NCS treatment (100ng/ml). (D) Histograms of MCF7, A549 and HCT116 cells stained for γH2AX at the indicated time-points after NCS treatment (N > 200 cells from 2 independent experiments.). (E) γH2AX in HCT116 cells was quantified 30 min and 8 hours after NCS treatment. (F) DNA damage assessed as γH2AX abundance at 30 min and 8 hours in the indicated cell lines were compared across a range of NCS concentrations (noted in the color scale). Data are means ± S.D. (N=7 doses).

Journal: Science signaling

Article Title: Dynamics of p53 in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM

doi: 10.1126/scisignal.aah6671

Figure Lengend Snippet: (A) A549 cells expressing p53-YFP were pre-treated with DMSO (NT) or Olaparib (PARPi; 10uM), NU7026 (DNA-PKi; 10uM), or CH99021 (GSK3βi; 10uM) for 1hr and then treated with NCS (100 ng/ml). Red lines represent the treated condition (thin lines, single cells; thick line, average), and the blue line represents the control (NT) cells (N>40 cells, representative of 2 independent experiments.). (B) Quantification of γH2AX intensity induced by NCS (100ng/ml; DNA damage) was measured in A549 cells after 1hr pretreatment with DMSO (NT) or the indicated inhibitor (10uM) 6 hours after treatment with 10Gy IR. Scale bar, 25μm. Histograms are shown, with a red line indicating the median (N>500 cells, representative 3 independent experiments.). (C) Images of cells from the indicated lines stained for γH2AX before or 0.5 or 24 hours after NCS treatment (100ng/ml). (D) Histograms of MCF7, A549 and HCT116 cells stained for γH2AX at the indicated time-points after NCS treatment (N > 200 cells from 2 independent experiments.). (E) γH2AX in HCT116 cells was quantified 30 min and 8 hours after NCS treatment. (F) DNA damage assessed as γH2AX abundance at 30 min and 8 hours in the indicated cell lines were compared across a range of NCS concentrations (noted in the color scale). Data are means ± S.D. (N=7 doses).

Article Snippet: X-ray induced DNA damage was generated with a RS-2000 source (RadSource).

Techniques: Expressing, Control, Staining